Our research focuses on understanding the processes that contribute to the organization of chromosomes. We aim to decipher the functional role of this chromosomal organization in the essential metabolisms of DNA, such as the repair of double-strand breaks, essential for genomic integrity or transcription in the early stages of differentiation.
Up to $4,500. Recipients for this internship must be enrolled at Stanford the quarter following the completion of the project for which they received funding. Thus, students who wish to pursue a fellowship the summer after their senior year may do so, but only if they apply for and receive permission from the University Registrar to enroll for a “graduation quarter” the following fall. For more information on graduation quarters, please visit: http://www.stanford.edu/dept/registrar/bulletin1011/4941.htm
The genome integrity is fundamental to cell identity and its disruption can underly cancerogenesis. We recently discovered in the unicellular eucaryote, Saccharomyces cerevisiae, that chromatin becomes more mobile upon DNA damages. Chromatin mobility is related to histone postranslation modifications that impact chromatin structure1.
This internship proposes to participate in the understanding of the molecular mechanisms by which chromatin mobility happens.
The student will use a battery of molecular genetics tools together with high-trough put in vivo microscopy and image analyses.
The student should have a good know-how in molecular and cell biology.
1. Herbert, S. et al. Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast. EMBO J36, 2595–2608 (2017).
English is spoken in the lab. French is helpful, but not required.
This internship is open to undergraduate students at any level (Freshman to Senior level). The student should have a meaningful background in molecular and cellular biology.
Applicants should submit the following documents combined in one single document (PDF or word format):
Completed application form (1 page).
Itemized budget (1 page).
Letter to be addressed to the France-Stanford Center Director describing your research interests and why you are applying for the position. Please explain the nature of your background and skills in molecular and cellular biology. Where and how did you acquire the relevant training? Are there particular courses you took, particular research projects you pursued, etc.? (800 words)
Recommendation letter from the applicant’s advisor, discussing the applicant and the merits of the proposed visit (1 page). Request this recommendation on your application form.